In the field of scientific instruments, mass spectrometer, as an important analytical tool, has long been monopolized by foreign brands. However, with the continuous enhancement of China's scientific and technological strength, the voice of domestic substitution is rising. On August 1, 2024, on this special day, looking back on the process of domestic replacement of mass spectrometers, we have seen the hardships and achievements from project approval to technological breakthroughs in core components, especially the outstanding contribution made by Sanboyi in the parts and components of quadrupole mass analyzers.